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The best time to take vitamin tablets varies depending on the type of vitamin and your individual needs. Generally, its recommended to take water-soluble vitamins (like B vitamins and vitamin C) in the morning on an empty stomach for optimal absorption, while fat-soluble vitamins (like A, D, E, and K) are best absorbed when taken with a meal containing some fat. For multivitamins, taking them with a meal is usually recommended to minimize stomach upset and aid absorption of both water-soluble and fat-soluble vitamins.